Theoretical aspects of applying sib-pair linkage tests to livestock species
نویسندگان
چکیده
منابع مشابه
Accurate inference of relationships in sib-pair linkage studies.
Relative-pair designs are routinely employed in linkage studies of complex genetic diseases and quantitative traits. Valid application of these methods requires correct specification of the relationships of the pairs. For example, within a sibship, presumed full sibs actually might be MZ twins, half sibs, or unrelated. Misclassification of half-sib pairs or unrelated individuals as full sibs ca...
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An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a lo...
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An improved sib-pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi-squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact power comparisons are made with the previously proposed tests. The new test is shown to be more powerful for f...
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There has been a growing interest in developing strategies for identifying single-nucleotide polymorphisms (SNPs) that explain a linkage signal by joint modeling of linkage and association. We compare several existing methods and propose a new method called the homozygote sharing transmission-disequilibrium test (HSTDT) to detect linkage and association or to identify SNPs explaining the linkag...
متن کاملHaseman and Elston sib-pair linkage analysis: a brief historical note.
Forty years ago, Steven G. Vandenberg and I founded Behavior Genetics (Vandenberg and DeFries 1970). Because one of the most frequently cited articles in human genetics (Haseman and Elston 1972) was published in the first issue of Volume 2 of this journal, its current Executive Editor, John K. Hewitt, agreed that this might be an appropriate time to share my recollections regarding the publicat...
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ژورنال
عنوان ژورنال: Genetics Selection Evolution
سال: 1992
ISSN: 1297-9686
DOI: 10.1186/1297-9686-24-1-29